Serologic follow-up of IgG responses against recombinat mycobacterial proteins ML0405, ML2331 and LID-1 in a leprosy hyperendemic area in Venezuela
Leprosy is a slowly evolving disease that occurs mainly in adults. In this study, the Mamaría Village, state of Portuguesa was selected because it had one of the highest rates (13.25%) of leprosy cases in 1997. Between1998-2004, 20.2% of the 89 cases registered in this village were less than 15 year...
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| On-line přístup: | http://hdl.handle.net/10872/13005 |
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| bitstream.checksum.fl_str_mv | 7c020282d630887ba819753d2e4a4c58 cfdf8b009f7e3e29f20f5b37dceca209 |
| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 |
| bitstream.url.fl_str_mv | https://saber.ucv.ve/jspui/bitstream/10872/13005/2/license.txt https://saber.ucv.ve/jspui/bitstream/10872/13005/1/Ig%20G%20seguimiento%20IMOC.pdf |
| dc.contributor.author.none.fl_str_mv | Rada, Elsa Duthie, Malcolm S Reed, Steven G Aranzazu, Nacarid Convit, Jacinto |
| dc.creator.fl_str_mv | Rada, Elsa Duthie, Malcolm S Reed, Steven G Aranzazu, Nacarid Convit, Jacinto |
| dc.date.accessioned.none.fl_str_mv | 2015-12-08T18:19:06Z |
| dc.date.available.none.fl_str_mv | 2015-12-08T18:19:06Z |
| dc.date.issued.none.fl_str_mv | 2012-07-18 |
| dc.identifier.issn.none.fl_str_mv | 1678-8060 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/10872/13005 |
| dc.language.iso.es_VE.fl_str_mv | en |
| dc.subject.es_VE.fl_str_mv | leprosy prevalencia incidence serology recombinant proteins |
| dc.title.es_VE.fl_str_mv | Serologic follow-up of IgG responses against recombinat mycobacterial proteins ML0405, ML2331 and LID-1 in a leprosy hyperendemic area in Venezuela |
| dc.type.es_VE.fl_str_mv | Article |
| description | Leprosy is a slowly evolving disease that occurs mainly in adults. In this study, the Mamaría Village, state of Portuguesa was selected because it had one of the highest rates (13.25%) of leprosy cases in 1997. Between1998-2004, 20.2% of the 89 cases registered in this village were less than 15 years old and 61.8 % were males. Paucibacillary (PB) lesions were the predominant clinical forms identified, although also multibacillary (MB) forms were found. Additionally, 76% of the patients were bacteriologically negative. At the time of diagnosis, 75% of the patients presented with grade 0 disabilities, 23 % with grade 1 and 2 % with grade 2. Serum samples were colleted from 18 PB and 15 MB, in addition to 14 family contacts, at the beginning and end of treatment. All the groups were re-evaluated during a three-year period (2008-2011). The proteins used for evaluation were ML0405, ML2331 and LID-1. These mycobacterial proteins were highly specific for Mycobacterium leprae and the IgG responses decreased in both MB and PB patients during multidrug treatment. Our results suggest that these antigens could be used as markers for successful treatment of non-reactional lepromatous patients. |
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| identifier_str_mv | 1678-8060 |
| language_invalid_str_mv | en |
| network_acronym_str | SABERUCV |
| network_name_str | Repositorio Institucional de la Universidad Central de Venezuela |
| oai_identifier_str | oai:saber.ucv.ve:10872/13005 |
| publishDate | 2012 |
| publishDateSort | 2012 |
| repository.mail.fl_str_mv | sfwrussians@gmail.com |
| repository.name.fl_str_mv | Saber UCV |
| repository_id_str | |
| spelling | Rada, ElsaDuthie, Malcolm SReed, Steven GAranzazu, NacaridConvit, Jacinto2015-12-08T18:19:06Z2015-12-08T18:19:06Z2012-07-181678-8060http://hdl.handle.net/10872/13005Leprosy is a slowly evolving disease that occurs mainly in adults. In this study, the Mamaría Village, state of Portuguesa was selected because it had one of the highest rates (13.25%) of leprosy cases in 1997. Between1998-2004, 20.2% of the 89 cases registered in this village were less than 15 years old and 61.8 % were males. Paucibacillary (PB) lesions were the predominant clinical forms identified, although also multibacillary (MB) forms were found. Additionally, 76% of the patients were bacteriologically negative. At the time of diagnosis, 75% of the patients presented with grade 0 disabilities, 23 % with grade 1 and 2 % with grade 2. Serum samples were colleted from 18 PB and 15 MB, in addition to 14 family contacts, at the beginning and end of treatment. All the groups were re-evaluated during a three-year period (2008-2011). The proteins used for evaluation were ML0405, ML2331 and LID-1. These mycobacterial proteins were highly specific for Mycobacterium leprae and the IgG responses decreased in both MB and PB patients during multidrug treatment. Our results suggest that these antigens could be used as markers for successful treatment of non-reactional lepromatous patients.enleprosyprevalenciaincidenceserologyrecombinant proteinsSerologic follow-up of IgG responses against recombinat mycobacterial proteins ML0405, ML2331 and LID-1 in a leprosy hyperendemic area in VenezuelaArticleLICENSElicense.txtlicense.txttext/plain; charset=utf-81509https://saber.ucv.ve/jspui/bitstream/10872/13005/2/license.txt7c020282d630887ba819753d2e4a4c58MD52ORIGINALIg G seguimiento IMOC.pdfIg G seguimiento IMOC.pdfapplication/pdf766229https://saber.ucv.ve/jspui/bitstream/10872/13005/1/Ig%20G%20seguimiento%20IMOC.pdfcfdf8b009f7e3e29f20f5b37dceca209MD5110872/13005oai:saber.ucv.ve:10872/130052015-12-08 18:19:06.315Saber UCVsfwrussians@gmail.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 |
| spellingShingle | Serologic follow-up of IgG responses against recombinat mycobacterial proteins ML0405, ML2331 and LID-1 in a leprosy hyperendemic area in Venezuela leprosy prevalencia incidence serology recombinant proteins |
| title | Serologic follow-up of IgG responses against recombinat mycobacterial proteins ML0405, ML2331 and LID-1 in a leprosy hyperendemic area in Venezuela |
| title_full | Serologic follow-up of IgG responses against recombinat mycobacterial proteins ML0405, ML2331 and LID-1 in a leprosy hyperendemic area in Venezuela |
| title_fullStr | Serologic follow-up of IgG responses against recombinat mycobacterial proteins ML0405, ML2331 and LID-1 in a leprosy hyperendemic area in Venezuela |
| title_full_unstemmed | Serologic follow-up of IgG responses against recombinat mycobacterial proteins ML0405, ML2331 and LID-1 in a leprosy hyperendemic area in Venezuela |
| title_short | Serologic follow-up of IgG responses against recombinat mycobacterial proteins ML0405, ML2331 and LID-1 in a leprosy hyperendemic area in Venezuela |
| title_sort | Serologic follow-up of IgG responses against recombinat mycobacterial proteins ML0405, ML2331 and LID-1 in a leprosy hyperendemic area in Venezuela |
| topic | leprosy prevalencia incidence serology recombinant proteins |
| url | http://hdl.handle.net/10872/13005 |