Helper Activity by Human Large Granular Lymphocytes in in Vitro Immunoglobulin Synthesis
In the present study we have examined the effect of human large granular Iymphocytes (LGL) from health y donors on Ig synthesis by autologous B Iymphocytes. The results showed that this cell population has a consistent helper activity in pokeweed mitogen-activated cultures even when added at very lo...
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| Published: |
1987
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| Online Access: | http://hdl.handle.net/10872/14421 |
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| Summary: | In the present study we have examined the effect of human large granular Iymphocytes (LGL) from health y donors on Ig synthesis by autologous B Iymphocytes. The results showed that this cell population has a consistent helper activity in pokeweed mitogen-activated cultures even when added at very low numbers. LGL can mediate their effect by secreting soluble helper factors capable of modulating B-cell responses as evidenced by the enhancement of IgG and IgM production by supernatants obtained from LGL cultures. Preincubation with interferon gamma further potentiated the helper activity by LGL. |
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