Synthesis and leishmanicidal evaluation of sulfanyl‐and sulfonyl‐tethered functionalized benzoate derivatives featuring a nitroimidazole moiety

A series of new nitroimidazole-containing derivatives was synthesized by coupling of 2-[2-(2-methyl-5-nitro-1H-imidazol-1- l)ethylthio]ethanol with diversely substituted benzoic acids. Upon treatment with m-CPBA, 12 of these sulfanyl compounds were further oxidized to their sulfonyl analogs. All the...

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Publicat:	2020
Matèries:	Nitroimidazole‐containing derivatives Leishmania (V.) braziliensis Leishmania (L.) mexicana Antileishmanial activity Catecholic derivative Pyrogallolic derivative Visceral leishmaniasis (VL) Cutaneous leishmaniasis (CL) Mucocutaneous leishmaniasis (MCL) Pentavalent antimony compounds Miltefosine Nitroaromatic scaffolds Metronidazole analogs Synthesis Nuclear magnetic resonance (NMR) Infrared (IR) Biological evaluation LC50 values
Accés en línia:	http://hdl.handle.net/10872/23246
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