Cáncer renal: factores pronósticos clínicos y anatomopatológicos
To know clinical and anatomopathological prognostic factors in renal cell cancer patients treated at the IVSS Hospital Oncology Service January 2006 - January 2016. Materials and Methods: We retrospectively reviewed the medical histories of patients who met inclusion criteria. Clinical and anatomopa...
Tallennettuna:
| Julkaistu: |
2017
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| Aiheet: | |
| Linkit: | http://hdl.handle.net/10872/16413 |
| Tagit: |
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| Yhteenveto: | To know clinical and anatomopathological prognostic factors in renal cell cancer patients treated at the IVSS Hospital Oncology Service January 2006 - January 2016. Materials and Methods: We retrospectively reviewed the medical histories of patients who met inclusion criteria. Clinical and anatomopathological characteristics were analyzed. A multivariate study of survival variables and Kaplan-meier curves were performed. Results: 142 patients evaluated, mean age 54 years, male 59.9%. Symptoms in 81.7%, mainly low back pain and urine bloody. Hemoglobin average 12.6gr / dl. ECOG 0 87.3%. Tumor size> 7 cm 54.8%. Radical nephrectomy 94.4%. Clear cell histology 76.8%. Furhman II nuclear grade 33.9%. Lymphovascular invasion present 20.4%. Tumor necrosis present 23.2%. Main areas of lung, bone and liver metastasis. Median relapse-free interval 27 months. Median overall survival 33 months. Low back pain (p <0.013), T2, T3a and T4 (p <0.002), and TNM (p <0.001) proved to be unfavorable prognostic factors for relapse. In a multivariate analysis using the Cox model, performance status (p <0.03), lymph node invasion (p <0.002), lymphovascular invasion (p <0.008), necrosis (p <0.001) and presence of metastases (p <0.001), Independent prognostic factors were associated with mortality. At the end of the study, 73.6% of the patients were alive and 26.4% had died. Conclusions: We established prognostic factors in our population ECOG ≥ 2, nodal involvement, metastasis, angiolymphatic invasion and tumor necrosis. Full reports of pathological anatomy, Perform lymph node dissection, identify high-risk patients, in order to provide therapeutics and timely follow-up. |
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