Trypanosoma cruzi III from armadillos (Dasypus novemcinctus novemcinctus) from Northeastern Venezuela and its biological behavior in murine model. Risk of emergency of Chagas’ disease
Trypanosoma cruzi, etiological agent of Chagas’ disease, was isolated from armadillos (Dasypus novemcinctus novemcinctus) captured in rural communities Northeastern Venezuela from Nueva Esparta State (no endemic for Chagas’ disease), Monagas and Anzoátegui States (endemics). The isolates, geneticall...
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2012
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| Online Erişim: | http://hdl.handle.net/10872/7266 |
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| _version_ | 1870622067900022784 |
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| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 MD5 |
| bitstream.url.fl_str_mv | https://saber.ucv.ve/jspui/bitstream/10872/7266/2/license.txt https://saber.ucv.ve/jspui/bitstream/10872/7266/1/dasypus%20and%20cruzi.pdf https://saber.ucv.ve/jspui/bitstream/10872/7266/3/dasypus%20and%20cruzi.pdf.txt |
| dc.contributor.author.none.fl_str_mv | Morocoima, Antonio Carrasco, Hernan Herrera Cabrera, Leidi Maira Boadas, Johanna Chique, Jose |
| dc.creator.fl_str_mv | Morocoima, Antonio Carrasco, Hernan Herrera Cabrera, Leidi Maira Boadas, Johanna Chique, Jose |
| dc.date.accessioned.none.fl_str_mv | 2014-10-05T01:56:12Z |
| dc.date.available.none.fl_str_mv | 2014-10-05T01:56:12Z |
| dc.date.issued.none.fl_str_mv | 2012-08-01 |
| dc.identifier.citation.es_VE.fl_str_mv | Experimental Parasitology 132 (2012) 341–347 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/10872/7266 |
| dc.language.iso.es_VE.fl_str_mv | en |
| dc.publisher.es_VE.fl_str_mv | Elsevier. Experimental Parasitology |
| dc.subject.es_VE.fl_str_mv | Armadillo (Dasypus novemcinctus TcIII PCR–RFLP Venezuela |
| dc.title.es_VE.fl_str_mv | Trypanosoma cruzi III from armadillos (Dasypus novemcinctus novemcinctus) from Northeastern Venezuela and its biological behavior in murine model. Risk of emergency of Chagas’ disease |
| dc.type.es_VE.fl_str_mv | Article |
| description | Trypanosoma cruzi, etiological agent of Chagas’ disease, was isolated from armadillos (Dasypus novemcinctus novemcinctus) captured in rural communities Northeastern Venezuela from Nueva Esparta State (no endemic for Chagas’ disease), Monagas and Anzoátegui States (endemics). The isolates, genetically typed by PCR–RFLP as belonging to the TcIII DTU, have demonstrated in murine model heterogenic parasitemia, mortality and histotropism with marked parasitism in cardiac, skeletal, and smooth myocytes that showed correlation with lymphobasophilic inflammatory infiltrates. Our finding of T. cruzi infected armadillos in Isla Margarita (Nueva Esparta State), together with reports of triatomine vectors in this region, the accentuated synanthropy of armadillos, intense economic activity, migration due to tourism and the lack of environmental education programs all of them represent risks that could cause the emergence of Chagas’ disease in this area. This is the first report of the TcIII DTU in Northeastern Venezuela, thus widening the geographic distribution of this DTU. |
| id | SABERUCV_ef31d7ede2e48aae21ec48ff85d024af |
| identifier_str_mv | Experimental Parasitology 132 (2012) 341–347 |
| language_invalid_str_mv | en |
| network_acronym_str | SABERUCV |
| network_name_str | Repositorio Institucional de la Universidad Central de Venezuela |
| oai_identifier_str | oai:saber.ucv.ve:10872/7266 |
| publishDate | 2012 |
| publishDateSort | 2012 |
| repository.mail.fl_str_mv | sfwrussians@gmail.com |
| repository.name.fl_str_mv | Saber UCV |
| repository_id_str | |
| spelling | Morocoima, AntonioCarrasco, HernanHerrera Cabrera, Leidi MairaBoadas, JohannaChique, Jose2014-10-05T01:56:12Z2014-10-05T01:56:12Z2012-08-01Experimental Parasitology 132 (2012) 341–347http://hdl.handle.net/10872/7266Trypanosoma cruzi, etiological agent of Chagas’ disease, was isolated from armadillos (Dasypus novemcinctus novemcinctus) captured in rural communities Northeastern Venezuela from Nueva Esparta State (no endemic for Chagas’ disease), Monagas and Anzoátegui States (endemics). The isolates, genetically typed by PCR–RFLP as belonging to the TcIII DTU, have demonstrated in murine model heterogenic parasitemia, mortality and histotropism with marked parasitism in cardiac, skeletal, and smooth myocytes that showed correlation with lymphobasophilic inflammatory infiltrates. Our finding of T. cruzi infected armadillos in Isla Margarita (Nueva Esparta State), together with reports of triatomine vectors in this region, the accentuated synanthropy of armadillos, intense economic activity, migration due to tourism and the lack of environmental education programs all of them represent risks that could cause the emergence of Chagas’ disease in this area. This is the first report of the TcIII DTU in Northeastern Venezuela, thus widening the geographic distribution of this DTU.Consejo de Desarrollo Científico y Humanístico, Universidad Central de Venezuela (Project CDCH No. PG 03 31 4729 06); Fondo Nacional de Ciencia y Tecnología (FONACIT, Project Nos. G- 2005000406 and G-2005000827); Misión Ciencia (Project No. 2008000911-6) Venezuela.enElsevier. Experimental ParasitologyArmadillo (Dasypus novemcinctusTcIIIPCR–RFLPVenezuelaTrypanosoma cruzi III from armadillos (Dasypus novemcinctus novemcinctus) from Northeastern Venezuela and its biological behavior in murine model. Risk of emergency of Chagas’ diseaseArticleLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://saber.ucv.ve/jspui/bitstream/10872/7266/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINALdasypus and cruzi.pdfdasypus and cruzi.pdfapplication/pdf837154https://saber.ucv.ve/jspui/bitstream/10872/7266/1/dasypus%20and%20cruzi.pdfdeb26aeb2f5d0f34a41511e9dd99c733MD51TEXTdasypus and cruzi.pdf.txtdasypus and cruzi.pdf.txtExtracted texttext/plain41362https://saber.ucv.ve/jspui/bitstream/10872/7266/3/dasypus%20and%20cruzi.pdf.txt5ad9310aa13263a839bbd43682695ba5MD5310872/7266oai:saber.ucv.ve:10872/72662026-03-17 03:19:36.903Saber UCVsfwrussians@gmail.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 |
| spellingShingle | Trypanosoma cruzi III from armadillos (Dasypus novemcinctus novemcinctus) from Northeastern Venezuela and its biological behavior in murine model. Risk of emergency of Chagas’ disease Armadillo (Dasypus novemcinctus TcIII PCR–RFLP Venezuela |
| title | Trypanosoma cruzi III from armadillos (Dasypus novemcinctus novemcinctus) from Northeastern Venezuela and its biological behavior in murine model. Risk of emergency of Chagas’ disease |
| title_full | Trypanosoma cruzi III from armadillos (Dasypus novemcinctus novemcinctus) from Northeastern Venezuela and its biological behavior in murine model. Risk of emergency of Chagas’ disease |
| title_fullStr | Trypanosoma cruzi III from armadillos (Dasypus novemcinctus novemcinctus) from Northeastern Venezuela and its biological behavior in murine model. Risk of emergency of Chagas’ disease |
| title_full_unstemmed | Trypanosoma cruzi III from armadillos (Dasypus novemcinctus novemcinctus) from Northeastern Venezuela and its biological behavior in murine model. Risk of emergency of Chagas’ disease |
| title_short | Trypanosoma cruzi III from armadillos (Dasypus novemcinctus novemcinctus) from Northeastern Venezuela and its biological behavior in murine model. Risk of emergency of Chagas’ disease |
| title_sort | Trypanosoma cruzi III from armadillos (Dasypus novemcinctus novemcinctus) from Northeastern Venezuela and its biological behavior in murine model. Risk of emergency of Chagas’ disease |
| topic | Armadillo (Dasypus novemcinctus TcIII PCR–RFLP Venezuela |
| url | http://hdl.handle.net/10872/7266 |