Influence of CTLA-4 gene polymorphism in autoimmune and infectious diseases
Cell-mediated immunity requires costimulatory activity to initiate or inhibit antigen-specific T-cell responses. CTLA-4 is an inhibitory receptor expressed by activated and regulatory T cells. The single nucleotide polymorphism (SNP) 49 A/G of the CTLA-4 gene alters intracellular distribution of CTL...
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2009
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| Online Access: | http://hdl.handle.net/10872/4899 |
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