Synthesis and Antitrypanosomal and Mechanistic Studies of a Series of 2‑Arylquinazolin-4-hydrazines: A Hydrazine Moiety as a Selective, Safe, and Specific Pharmacophore to Design Antitrypanosomal Agents Targeting NO Release

Nitric oxide (NO) represents a valuable target to design antitrypanosomal agents by its high toxicity against trypanosomatids and minimal side effects on host macrophages. The progress of NO-donors as antitrypanosomal has been restricted by the high toxicity of their agents, which usually is based o...

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Bibliographic Details

Published:	2022
Subjects:	Nitric oxide (NO) Antitrypanosomal agents Trypanosomatids Macrophages Hydrazine moiety Leishmania Folate metabolism Antifolate agents
Online Access:	https://doi.org/10.1021/acsomega.2c06455 http://hdl.handle.net/10872/23244
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