Synthesis and Antitrypanosomal and Mechanistic Studies of a Series of 2‑Arylquinazolin-4-hydrazines: A Hydrazine Moiety as a Selective, Safe, and Specific Pharmacophore to Design Antitrypanosomal Agents Targeting NO Release
Nitric oxide (NO) represents a valuable target to design antitrypanosomal agents by its high toxicity against trypanosomatids and minimal side effects on host macrophages. The progress of NO-donors as antitrypanosomal has been restricted by the high toxicity of their agents, which usually is based o...
Guardat en:
| Publicat: |
2022
|
|---|---|
| Matèries: | |
| Accés en línia: | https://doi.org/10.1021/acsomega.2c06455 http://hdl.handle.net/10872/23244 |
| Etiquetes: |
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|
Ítems similars: Synthesis and Antitrypanosomal and Mechanistic Studies of a Series of 2‑Arylquinazolin-4-hydrazines: A Hydrazine Moiety as a Selective, Safe, and Specific Pharmacophore to Design Antitrypanosomal Agents Targeting NO Release
- Antitrypanosomal Activity of Quaternary Naphthalimide Derivatives
- Respuestas de inmunidad celular en la tuberculosis pulmonar.
- Synthesis of Benzocycloalkanone-Based Michael Acceptors and Biological Activities as Antimalarial and Antitrypanosomal Agents
- Experimental Leishmaniasis: The glibenclamide-triggered decrease in parasite growth correlates with changes in macrophage features.
- Diseño de una guía de orientación sobre las manifestaciones clínicas por agentes biológicos utilizados como armas terroristas, dirigidas al profesional de enfermería del Hospital Simón Bolívar, Caracas, 2008-2009
- Government urban management in San Agustín, Caracas: ¿A never ending symbiotic process?