Parto pretérmino: Prevención con el uso de progesterona natural
Objetive: To evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate in a high-risk population. Methods: A randomized, double-blind, placebo-controlled study included 48 high-risk singleton pregnancies. Progesterone (100 mg) or placebo was administered daily by vagi...
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| Published: |
2015
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| Online Access: | http://hdl.handle.net/10872/8123 |
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| Summary: | Objetive: To evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate in a high-risk population. Methods: A randomized, double-blind, placebo-controlled study included 48 high-risk singleton pregnancies. Progesterone (100 mg) or placebo was administered daily by vaginal suppository between 24 and 34 weeks of gestation. Progesterone (n: 24) and placebo (n: 24) groups were compared for epidemiologic characteristics, threatened preterm labor, preterm labor, birth weight, birth height, number of days of hospitalization. The results were described using frequencies, percentage, arithmetical mean, standard deviation and X2 test. A P value of < 0,05 was considered statistically significant. Statistical analysis was performed with SPSS Statistics 19® y STATS TM®. Results: The preterm birth rate was 4,1 % for the progesterone group vs. 29,2 % for the placebo group (p <0,01). The number of days of hospitalization was 2,4 ± 1,4 for the progesterone group and 7,2 ± 14,6 for the placebo group (p < 0,05). Conclusion: Prophylactic vaginal progesterone reduced the rate of preterm birth and the number of days of hospitalization of the newborns, in women at high-risk for prematurity. |
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