Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis
Recent studies have shown that mucocutaneous leishmaniasis (MCL), a severe and debilitating form of American cutaneous leishmaniasis (ACL) caused by Leishmania braziliensis infection, is accompanied by high circulating levels of tumor necrosis factor (TNF)-oL. Analysis of TNF polymorphisms in Venezu...
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1995
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| Online-Zugang: | http://hdl.handle.net/10872/4889 |
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| _version_ | 1870622047059574784 |
|---|---|
| bitstream.checksum.fl_str_mv | 13c8427d7bbd0804088593db51760682 8a4605be74aa9ea9d79846c1fba20a33 |
| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 |
| bitstream.url.fl_str_mv | https://saber.ucv.ve/jspui/bitstream/10872/4889/1/SNP%20TNF.pdf https://saber.ucv.ve/jspui/bitstream/10872/4889/2/license.txt |
| dc.contributor.author.none.fl_str_mv | Cabrera, Maira Shaw, Marie Anne Sharples, Claire Williams, Hazel Castes, Marianella Convit, Jacinto Blackwell, Jenefer M |
| dc.creator.fl_str_mv | Cabrera, Maira Shaw, Marie Anne Sharples, Claire Williams, Hazel Castes, Marianella Convit, Jacinto Blackwell, Jenefer M |
| dc.date.accessioned.none.fl_str_mv | 2013-11-15T16:28:43Z |
| dc.date.available.none.fl_str_mv | 2013-11-15T16:28:43Z |
| dc.date.issued.none.fl_str_mv | 1995-11 |
| dc.identifier.citation.es_VE.fl_str_mv | J.EXP.MED |
| dc.identifier.issn.none.fl_str_mv | 0022-1007 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/10872/4889 |
| dc.language.iso.es_VE.fl_str_mv | en |
| dc.publisher.es_VE.fl_str_mv | Journal of Experimental Medicine |
| dc.relation.ispartofseries.none.fl_str_mv | 182; |
| dc.subject.es_VE.fl_str_mv | mucocutaneous leishmaniasis TNF-alpha polimorphims |
| dc.title.es_VE.fl_str_mv | Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis |
| dc.type.es_VE.fl_str_mv | Article |
| description | Recent studies have shown that mucocutaneous leishmaniasis (MCL), a severe and debilitating form of American cutaneous leishmaniasis (ACL) caused by Leishmania braziliensis infection, is accompanied by high circulating levels of tumor necrosis factor (TNF)-oL. Analysis of TNF polymorphisms in Venezuelan ACL patients and endemic unaffected controls demonstrates a high relative risk (RR) of 7.5 (P <0.001) of MCL disease in homozygotes for allele 2 of a polymorphism in intron 2 of the TNF-[3 gene, especially in females (RR = 9.5; P <0.001) compared with males (RR = 4; P <0.05). A significantly higher frequency (P <0.05) of allele 2 at the -308-basepair TNF-c~ gene polymorphism was also observed in MCL patients (0.18) compared with endemic control subjects (0.069), again associated with a high relative risk of disease (RR = 3.5; P <0.05) even in the heterozygous condition. Because both the TNF-c~ and TNF-[3 polymorphisms have previously been linked with functional differences in TNF-oL levels, these data suggest that susceptibility to the mucocutaneous form of disease may be directly associated with regulatory polymorphisms affecting TNF-~x production |
| id | SABERUCV_d4e91c856ccd7c6ef0f33dae16911a08 |
| identifier_str_mv | J.EXP.MED 0022-1007 |
| language_invalid_str_mv | en |
| network_acronym_str | SABERUCV |
| network_name_str | Repositorio Institucional de la Universidad Central de Venezuela |
| oai_identifier_str | oai:saber.ucv.ve:10872/4889 |
| publishDate | 1995 |
| publishDateSort | 1995 |
| repository.mail.fl_str_mv | sfwrussians@gmail.com |
| repository.name.fl_str_mv | Saber UCV |
| repository_id_str | |
| spelling | Cabrera, MairaShaw, Marie AnneSharples, ClaireWilliams, HazelCastes, MarianellaConvit, JacintoBlackwell, Jenefer M2013-11-15T16:28:43Z2013-11-15T16:28:43Z1995-11J.EXP.MED0022-1007http://hdl.handle.net/10872/4889Recent studies have shown that mucocutaneous leishmaniasis (MCL), a severe and debilitating form of American cutaneous leishmaniasis (ACL) caused by Leishmania braziliensis infection, is accompanied by high circulating levels of tumor necrosis factor (TNF)-oL. Analysis of TNF polymorphisms in Venezuelan ACL patients and endemic unaffected controls demonstrates a high relative risk (RR) of 7.5 (P <0.001) of MCL disease in homozygotes for allele 2 of a polymorphism in intron 2 of the TNF-[3 gene, especially in females (RR = 9.5; P <0.001) compared with males (RR = 4; P <0.05). A significantly higher frequency (P <0.05) of allele 2 at the -308-basepair TNF-c~ gene polymorphism was also observed in MCL patients (0.18) compared with endemic control subjects (0.069), again associated with a high relative risk of disease (RR = 3.5; P <0.05) even in the heterozygous condition. Because both the TNF-c~ and TNF-[3 polymorphisms have previously been linked with functional differences in TNF-oL levels, these data suggest that susceptibility to the mucocutaneous form of disease may be directly associated with regulatory polymorphisms affecting TNF-~x productionThis investigation received financial support from the UNDP/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases, and from the Wellcome TrustenJournal of Experimental Medicine182;mucocutaneous leishmaniasisTNF-alphapolimorphimsPolymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasisArticleORIGINALSNP TNF.pdfSNP TNF.pdfapplication/pdf563127https://saber.ucv.ve/jspui/bitstream/10872/4889/1/SNP%20TNF.pdf13c8427d7bbd0804088593db51760682MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://saber.ucv.ve/jspui/bitstream/10872/4889/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5210872/4889oai:saber.ucv.ve:10872/48892013-11-15 16:28:43.761Saber UCVsfwrussians@gmail.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 |
| spellingShingle | Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis mucocutaneous leishmaniasis TNF-alpha polimorphims |
| title | Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis |
| title_full | Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis |
| title_fullStr | Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis |
| title_full_unstemmed | Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis |
| title_short | Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis |
| title_sort | Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis |
| topic | mucocutaneous leishmaniasis TNF-alpha polimorphims |
| url | http://hdl.handle.net/10872/4889 |